Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ovarian Cancer Chemoresistance

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6930-4

Definition

Ovarian cancer is the leading cause of death from gynecological malignancy in the western world. Worldwide there are more than 225,000 new cases of ovarian cancer each year, accounting for around 4 % of all cancers diagnosed in women. Ovarian cancer has remained the most challenging of all the gynecological malignancies for two reasons. First, early-stage ovarian cancer, which has a good prognosis, cannot be detected easily. Second, standard chemotherapy approaches such as paclitaxel and carboplatin often fail, and patients develop recurrent chemoresistant disease. Chemoresistance is a therapeutic problem that severely limits successful treatment outcomes for many human cancers. This is particularly true of ovarian cancer, where the development of resistance is a common occurrence.

Characteristics

Symptoms and Treatment of Ovarian Cancer

The symptoms of ovarian cancer are nonspecific and often occur when the disease is already spread throughout the abdominal cavity....

Keywords

Ovarian Cancer Epithelial Ovarian Cancer Nucleotide Excision Repair Platinum Drug Successful Treatment Outcome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Departments of Obstetrics and Gynaecology/HistopathologyTrinity College Dublin, Trinity Centre for Health SciencesDublinIreland