Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

BORIS

  • Dmitri Loukinov
  • Elena Klenova
  • Victor Lobanenkov
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_691-9

Synonyms

Definition

BORIS (acronym for Brother of the Regulator of Imprinted Sites) is a member of Cancer–Testis Antigen (CTA) family and a mammalian paralogue of CTCF, with the suggested role in the regulation of epigenetic reprogramming.

Characteristics

Studies on a transcription factor CTCF, a candidate tumor suppressor gene (TSG) involved in transcriptional regulation, control of imprinted genes, and insulators, led to a discovery of its paralogue, termed BORIS. The rationale behind the discovery of BORIS was to explain the process of resetting of imprintingmarks in testis, in other words, how methylation-sensitive CTCF binding sites can be established in germ cells de novo. The existence of a protein with certain characteristics in these cells was therefore postulated. On the one hand, such a hypothetic protein needed to recognize the same DNA sequences as CTCF to...

Keywords

Epigenetic Reprogram CTCF Binding Site Normal Human Dermal Fibroblast Imprint Site Biochemical Machinery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Klenova EM, Morse HC III, Ohlsson R et al (2002) The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol 12:399–414CrossRefPubMedGoogle Scholar
  2. Loukinov D, Pugacheva E, Vatolin S et al (2002) BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A 99:6806–6811CrossRefPubMedPubMedCentralGoogle Scholar
  3. Ohlsson R, Lobanenkov V, Klenova E (2010) Does CTCF mediate between nuclear organization and gene expression? Bioessays 32:37–50CrossRefPubMedGoogle Scholar
  4. Pugacheva EM, Suzuki T, Pack SD (2010) The structural complexity of the human BORIS Gene in gametogenesis and cancer. PLoS One 5(11):e13872CrossRefPubMedPubMedCentralGoogle Scholar
  5. Suzuki T, Kosaka-Suzuki N, Pack S (2010) Expression of a testis-specific form of Gal3st1 (CST), a gene essential for spermatogenesis, is regulated by the CTCF paralogous gene BORIS. Mol Cell Biol 30:2473–2484CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) ARF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 265. doi: 10.1007/978-3-642-16483-5_383Google Scholar
  2. (2012) Biomarkers. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 408-409. doi: 10.1007/978-3-642-16483-5_6601Google Scholar
  3. (2012) C-Myc. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 886. doi: 10.1007/978-3-642-16483-5_1232Google Scholar
  4. (2012) CTCF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1007. doi: 10.1007/978-3-642-16483-5_1403Google Scholar
  5. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Dmitri Loukinov
    • 1
  • Elena Klenova
    • 2
  • Victor Lobanenkov
    • 1
  1. 1.Section of Molecular Pathology, Laboratory of ImmunopathologyNIAID, National Institutes of HealthBethesdaUSA
  2. 2.Department of Biological SciencesUniversity of EssexColchesterUK