Bone Loss Cancer Mediated
Living reference work entry
Metastasis describes the spread of cancer from its site of origin (the “primary site”) to another location in the body (the “secondary site”). The bone is the most frequent site affected by metastatic cancer. While any type of cancer can spread to the bone, metastatic bone disease is most commonly associated with cancers whose primary origin is the breast, prostate, or lung. Although less common, bone metastases are also associated with cancers arising in the thyroid, kidney, stomach, uterus, colon, bladder, and rectum (Table 1). Metastasis of cancer to the bone often results in significant skeletal morbidity which manifests as severe bone pain, pathologic fractures, spinal cord compression, and life-threatening hypercalcemia.
Incidence of primary tumors...
KeywordsMultiple Myeloma Bone Metastasis Bone Matrix Connective Tissue Growth Factor Vicious Cycle
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