Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Colorectal Cancer Pathology

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6772-6

Definition

Colorectal carcinoma comprises all malignant epithelial tumors of the colon and rectum, the most frequent of which is colorectal adenocarcinoma. Unlike in the stomach or small intestine, only tumors that have invaded through the muscularis mucosae into the submucosa are considered malignant in the colon and rectum thus being called invasive carcinoma by the World Health Organization (WHO) classification (Bosman et al. 2010; UICC 2009). This is due to the fact that in the colon and rectum, a neoplasm has malignant potential only after invasion of the submucosa, where lymphatic vessels are located. Unfortunately, the term “carcinoma” is not used uniformly. This especially applies to the intermediate lesions between intraepithelial neoplasia (dysplasia) and invasive carcinoma that show invasion into the lamina propria mucosae or between the fibers of the muscularis mucosae without invading the submucosa. Hence, one has to be careful to avoid being misled by statistics and...

Keywords

Colorectal Carcinoma Rectal Carcinoma Signet Ring Cell Venous Invasion Serrate Polyp 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

References

  1. Bosman FT, Carneiro F, Hruban RH et al (eds) (2010) World Health Organization (WHO) classification of tumors. Pathology & genetics. Tumors of the digestive system. IARC Press, LyonGoogle Scholar
  2. Compton CC, Fielding LP, Burgart LJ et al (2000) Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 124:979–994PubMedGoogle Scholar
  3. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN (2008) Gastrointestinal pathology: an atlas and text, 3rd edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  4. Hermanek P (2002) Pathology of colorectal cancer. In: Bleiberg H, Kemeny N, Rougier P et al (eds) Colorectal cancer. A clinical guide to therapy. M. Dunitz, London, p 55 et seqGoogle Scholar
  5. Neid M, Tannapfel A, Wittekind C (2008) Gastrointestinal tumours. Histological regression grading after neoadjuvant therapy. Onkologe 14:409–418CrossRefGoogle Scholar
  6. UICC (2009) In: Sobin LH, Gospodarowicz MK, Wittekind C (eds) TNM classification of malignant tumours, 7th edn. Wiley-Blackwell, OxfordGoogle Scholar
  7. Washington MK, Berlin J, Branton P et al (2009) Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum. Arch Pathol Lab Med 133:1539–1551PubMedPubMedCentralGoogle Scholar
  8. Wittekind C (2007) Pathology. In: Cassidy J, Johnston P, van Cutsem E (eds) Colorectal cancer. Informa Healthcare USA, New York, p 103 et seqGoogle Scholar
  9. Wittekind Ch, Koch HK (2005) Empfehlungen zur pathologisch-anatomischen Diagnostik des kolorektalen Karzinoms des Berufsverbandes Deutscher Pathologen e.V. und der Deutschen Gesellschaft für Pathologie e.V., Version 1.0. http://www.bv-pathologie.de/mitgliederbereich/download.php?f=leit-linie_kolo_karzinom.pdf. Accessed Feb 2010
  10. Wittekind C, Compton CC, Brierley J et al (2012) UICC TNM supplement. A commentary on uniform use, 4th edn. Wiley-Blackwell, OxfordGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department für Diagnostik, Institut für PathologieUniversitätsklinikum LeipzigLeipzigGermany