Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Colon Cancer Genomic Pathways

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6564-2

Synonyms

Definition

Colon carcinogenesis is thought to result from genomic changes – mutation, deletion, chromosome translocation, or epigenetic modifications – in genes controlling the normal balance between proliferation (oncogene) and cell death (Apoptosis) (tumor suppressor gene), which appears in normal the epithelial cell of the colon and leading to a deregulation of the cell homeostasis. The mutated cells can first constitute preneoplastic lesions (Colorectal Cancer Premalignant Lesions), then adenoma (benign tumors), and later on carcinoma able to lead to metastasis of the liver.

Characteristics

Histopathological Characteristics

In the colon adenoma-carcinoma sequence, the earliest identifiable lesion corresponds to small dysplastic lesions within the colonic epithelium named aberrant crypt foci (ACF). These preneoplastic lesionshave been defined as crypts that: (i) are larger than the normal crypts in the field, (ii) have increased...

Keywords

Familial Adenomatous Polyposis Lynch Syndrome Mismatch Repair Dextrane Sodium Sulfate Rectal Prolapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.INSERM U.858, Institut de Médecine Moléculaire de Rangueil, IFR150Université Paul SabatierToulouseFrance