Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Urothelial Carcinoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6123-4

Synonyms

Definition

Urothelial carcinoma is a cancer arising from the urothelium, a specialized epithelium lining the urinary tract from the renal pelvis into the urethra, retaining discernible morphological aspects and molecular markers of urothelial cells.

Characteristics

Distribution, Histology, and Clinical Course

Urothelial carcinomas (UCs) arise from the urothelium, an epithelium lining the urinary tract from the renal pelvis into the urethra. Most tumors initiate in the urinary bladder, but some are localized in the urethra, the renal pelvis, and the ureters. Tumors arising in the upper urinary tract are somewhat different with respect to etiology and molecular genetics. Urothelial carcinoma is the most common histological subtype of bladder cancer in most countries, often retaining aspects of normal urothelial differentiation including markers like cytokeratins 7, 13, and 20 and uroplakins. Another histological...

Keywords

Bladder Cancer Lynch Syndrome Urothelial Carcinoma Tuberous Sclerosis Complex Urothelial Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of UrologyHeinrich Heine UniversityDüsseldorfGermany