Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Toll-Like Receptors

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5855-2

Definition

Toll-like receptors (TLRs) represent a family of proteins that are involved in the innate sensing of conserved microbial components. They are composed of an extracellular domain containing leucine-rich repeats and a cytoplasmic Toll/interleukin-1 receptor/resistance (TIR) domain that is responsible for mediating downstream signaling cascades and subsequent inflammatory response, ultimately leading to the eradication of infectious agents.

Characteristics

Toll-like receptors were originally described as proteins with homology to the protein Toll, which was first identified in Drosophila melanogaster. In flies, Toll served a regulatory function in the embryonic dorsoventral polarity and was later shown to be an essential component of the Drosophilainnate immune system. Based on the fact that Toll serves an immune function in Drosophila, it was proposed that TLRs might “activate adaptive immunity” in mammals, but the precise function of TLRs was revealed by forward genetics.

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Keywords

Basal Cell Carcinoma Actinic Keratose Adaptor Molecule Cutaneous Metastasis Allogeneic Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Beutler B (2004) Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430:257–263CrossRefPubMedGoogle Scholar
  2. IshiiK J, Coban C, Akira S (2005) Manifold mechanisms of toll-like receptor-ligand recognition. J Clin Immunol 25:511–521CrossRefGoogle Scholar
  3. O’NeillL A (2006) How Toll-like receptors signal: what we know and what we don’t know. Curr Opin Immunol 18:3–9CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Division of ImmunobiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA