Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Thymoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5802-2

Definition

An epithelial neoplasm derived from the thymic epithelium.

Characteristics

Thymomas are among the most common epithelial tumors of the thymic gland. The tumor may occur at any age, but it is very unusual for this neoplasm to occur in the pediatric age group. The tumor is most likely to occur in adult individuals of over 40 years of age. The most common anatomic site is in the anterior mediastinum. However, in rare instances, thymomas may also arise in the lung, pleura, and neck. Clinically, patients with thymomas may be completely asymptomatic, and their tumors may become apparent during a routine physical examination. Radiological studies will disclose the presence of an anterior mediastinal mass. On the other hand, thymomas may be associated with other medical conditions such as myasthenia gravis. In some series, myasthenia gravis has been associated with thymomas as high as 30–60 % of the cases. Although myasthenia gravis is often associated with thymomas, a long and wide...

Keywords

Cytologic Atypia Anterior Mediastinum Routine Physical Examination Anterior Mediastinal Mass Nodular Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Marx A, Strobel P, Zettl A et al (2004) Thymomas. In: Travis WD, Brambilla E, Muller-Hermelink K et al (eds) Pathology and genetics. Tumours of the lung, pleura, thymus, and heart. International Agency for Research on Cancer (IARC), Lyon, pp 152–171Google Scholar
  2. Rieker RJ, Hoegel J, Morresi-Hauf A et al (2002) Histologic classification of thymic epithelial tumors: comparison of established classification schemes. Int J Cancer 98:900–906CrossRefPubMedGoogle Scholar
  3. Suster S, Moran CA (1999) Thymoma, atypical thymoma, and thymic carcinoma: a novel conceptual approach to the classification of neoplasms of thymic epithelium. Am J Clin Pathol 111:826–833CrossRefPubMedGoogle Scholar
  4. Suster S, Moran CA (2005) Problems and inconsistencies in the WHO classification of thymoma. Semin Diagn Pathol 22:188–197CrossRefPubMedGoogle Scholar
  5. Suster S, Moran CA (2006) Thymoma classification: current status and future trends. Am J Clin Pathol 125:542–554CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyM D Anderson Cancer CenterHoustonUSA