Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

TCL1

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5706-2

Definition

The TCL1 gene is involved in the generation and/or manifestation of mature forms of leukemias, mainly in the T-Prolymphocytic leukemia (T-PLL) and in chronic lymphocytic leukemia (B-CLL).

Characteristics

Clinical Characteristics of the T-PLL

T-PLL is a disease that represents 20 % of prolymphocytic leukemias. It occurs at an advanced age of 70–80 years, with a slight male predominance. It is, however, quite frequent in patients with the immunodeficiency syndrome ataxia-telangiectasia (AT) (1–5 % of these patients develop it). Clinically, it is accompanied by splenomegaly (75 %), hepatomegaly (42 %), lymphadenopathy (55 %), and a high blood count (>200 × 109/L), with a very bad survival rate (<8 months). It involves mature T-cells (CD4+ in the 65 % but also CD8+ and CD4+ CD8+); T-cell prolymphocytes usually express CD3, CD5, and CD7. Morphologically, the T-prolymphocyte is smaller than its B-counterpart, usually with a single, sometimes irregular nucleolus. Chromosomal...

Keywords

Chronic Lymphocytic Leukemia Chronic Leukemia Prolymphocytic Leukemia Preimplantation Embryo Development Immunoblastic Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bichi R, Shinton SA, Martin ES et al (2002) Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A 99:6955CrossRefPubMedPubMedCentralGoogle Scholar
  2. Pekarsky Y, Koval A, Hallas C et al (2000) Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci U S A 97:3028CrossRefPubMedPubMedCentralGoogle Scholar
  3. Teitell MA (2005) The TCL1 family of oncoproteins: co-activators of transformation. Nat Rev Cancer 5:640CrossRefPubMedGoogle Scholar
  4. Virgilio L, Narducci MG, Isobe M et al (1994) Identification of the TCL1 gene involved in T-cell malignancies. Proc Natl Acad Sci U S A 91:12530CrossRefPubMedPubMedCentralGoogle Scholar
  5. Virgilio L, Lazzeri C, Bichi R et al (1998) Deregulated expression of TCL1 causes T cell leukemia in mice. Proc Natl Acad Sci U S A 95:3885CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Istituto Dermopatico dell’ImmacolataIstituto di Ricovero e Cura a Carattere ScientificoRomaItaly