Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Synuclein

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5631-2

Definition

Synucleins are small cytosolic proteins of uncertain function, normally expressed at high levels in the vertebrate nervous system. Increased expression of synuclein proteins, especially γ-synuclein, is associated with progression of a variety of tumors.

Characteristics

The precise function of the synuclein proteins is not well understood. All family members (α-synuclein, SNCA; β-synuclein, SNCB; and γ-synuclein, SNCG) share a conserved domain related to the lipid-binding domains of the exchangeable apolipoproteins, the major lipid transporters in blood. This conserved domain mediates reversible interactions with lipid membranes. α-Synuclein regulates the uptake and incorporation of fatty acids into phospholipids, and mutations in α-synuclein alter the composition of cellular membranes.

Each of the synuclein isoforms possesses a unique tail domain, which may mediate distinct physiological actions. α-Synuclein and β-synuclein are normally expressed in the central nervous...

Keywords

Burkitt Lymphoma Cell Epigenetic Gene Silence Estrogen Receptor Pathway Mitotic Spindle Checkpoint Burkitt Lymphoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ahmad M, Attoub S, Singh MN et al (2007) Gamma-synuclein and the progression of cancer. FASEB J 21:3419–3430CrossRefPubMedGoogle Scholar
  2. George JM (2002) The synucleins. Genome Biol 3: Reviews3002Google Scholar
  3. Lavedan C (1998) The synuclein family. Genome Res 8:871–880PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Queen Mary University of LondonLondonUK