Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Synovial Sarcoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5627-2

Definition

Human synovial sarcomas are soft tissue tumors that account for up to 10 % of all human sarcomas and mainly affect children and young adults. These tumors display relatively high rates of local recurrences and metastases (metastasis) and are therefore regarded as high grade tumors. Five- and ten-year survival rates of 60–80 % and 40–50 %, respectively, have been reported in several large retrospective studies. The tumors occur most frequently in the extremities (often associated with the large joints), but may also be encountered in a wide variety of organs. The name synovial sarcomas is misleading since it has become clear that they do not originate from synovial tissue. Instead, synovial sarcomas are thought to be derived from progenitor cells that are capable of differentiating into mesenchymal and/or epithelial structures. A very recent study indicated that these progenitor cells may, in fact, be primary myocytes. Histopathologically, synovial sarcomas can be subdivided...

Keywords

Synovial Sarcoma Transcriptional Regulatory Activity Synovial Sarcoma Cell Transcription Regulatory Activity Specific Chromosomal Translocation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. de Bruijn DRH, Nap JP, van Geurts Kessel A (2007) The (epi)genetics of human synovial sarcoma. Genes Chromosomes Cancer 46:107–117CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Human GeneticsRadboud University Nijmegen Medical CentreNijmegenThe Netherlands