Syk Tyrosine Kinase
Syk tyrosine kinase activity was originally recognized in the spleen, thymus, and lung and was later cloned from spleen. A 72 kDa protein, Syk contains 635 amino acids and the human gene maps to chromosome 9q22. It contains two N-terminal, SH2 domains in tandem and a C-terminal tyrosine kinase domain. Interdomain A separates the tandem SH2 domains, and interdomain B links the kinase domain to the tandem SH2 domains. An alternatively spliced site in interdomain B deleting 23 amino acids gives rise to a short form of Syk that can be differently expressed according to the tissue. Syk together with the related Zap70 (zeta-activated protein of 70 kDa) constitute a separate tyrosine kinase family.
Distribution and Function
Syk is critical to immune cell signaling where it promotes proliferation, survival, phagocytosis, and differentiation and is required for lymphocyte development, innate immune recognition, osteoclast...
KeywordsMantle Cell Lymphoma Oral Squamous Cell Carcinoma Epigenetic Gene Silence Breast Cancer Patient Outcome Transmembrane Integrin Receptor
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