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Encyclopedia of Cancer pp 1–4Cite as

SV40

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Synonyms

Simian virus 40

Definition

A DNA tumor virus (genus Polyomavirus) was found to be a contaminant of Salk and Sabin polio vaccines (1955–1961) that propagates naturally in kidney cell lines of Asian macaque species, specifically the rhesus and African green monkey. SV40 in these species, and related primates, produces no cytopathic effects upon the animals, but the virus injected into hamsters and other rodents causes ependymomas, lymphomas, osteosarcomas, sarcomas, and mesotheliomas. Subsequent research has shown a possible correlation between SV40 (Fig. 1) and human mesotheliomas.

Fig. 1
figure 1

Electron micrograph (250,000×) of SV40 virions (Kindly provided by Dr. R. Fresco)

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References

  • Bocchetta M, Eliasz S, Arakelian De Marco M, Rudzinski J, Zhang L, Carbone M (2008) The SV40 large T Antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth. Cancer Res, 68: 1022–1029.

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  • Carbone M (1999) Carbone M (1999) Simian virus 40 and human tumors: It is time to study mechanisms. J Cell Biochem, 76(2):189–193.

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  • Cutrone R, Lednicky J, Dunn G et al (2005) Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961. Cancer Res 65:10273–10279

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  • Gazdar AF and Carbone M (2003) Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40. Clin Lung Cancer, 5:177–181.

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  • Kroczynska B, Cutrone R, Bocchetta M et al (2006) Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters. Proc Natl Acad Sci U S A 103:14128–14133

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. University of Hawaii Cancer Center, Honolulu, HI, USA

    Michele Carbone & Haining Yang

Authors
  1. Michele Carbone
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  2. Haining Yang
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Corresponding author

Correspondence to Michele Carbone .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Carbone, M., Yang, H. (2015). SV40. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5610-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5610-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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