Living reference work entry
A DNA tumor virus (genus Polyomavirus) was found to be a contaminant of Salk and Sabin polio vaccines (1955–1961) that propagates naturally in kidney cell lines of Asian macaque species, specifically the rhesus and African green monkey. SV40 in these species, and related primates, produces no cytopathic effects upon the animals, but the virus injected into hamsters and other rodents causes ependymomas, lymphomas, osteosarcomas, sarcomas, and mesotheliomas. Subsequent research has shown a possible correlation between SV40 (Fig. 1) and human mesotheliomas.
KeywordsMesothelial Cell Human Mesothelial Cell Monkey Kidney Cell Line SV40 Genome Rhesus Monkey Kidney Cell
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