A contagious veneral tumor found in the domestic dog and potentially in their social canids, such as the gray wolf and the coyote. The tumor cells themselves, rather than another agent such as a virus, constitute the contagious agent of the disease. CTVT is passed through the population by allografts, with the tumor cells from one animal directly seeding tumor formation in the next, usually during coitus. The tumor cells carry a particular marker, common to all tumors in the different host animals, which consists in a diagnostic long interspersed nuclear element (LINE-1) near the MYC Oncogene gene. The cells of any canine host do not have this diagnostic LINE-1 insertion. Thus, all tumors represent a single cell lineage that has been propagated over long time. The mechanism for tumor cells to evade the host immune system is not clear.
KeywordsTumor Cell Immune System Cancer Research Single Cell Tumor Formation
- (2012) Allograft. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 142. doi:10.1007/978-3-642-16483-5_199.Google Scholar
- (2012) LINE. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2041. doi:10.1007/978-3-642-16483-5_3359.Google Scholar