Living reference work entry
STI-571 is a small compound belonging to the phenylaminopyrimidine class of compounds (Fig. 1). It is chemically designed as 4-[(4-methyl-1-piperazinyl)methyl]- N-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamidine methanesulfonate, with a molecular formula of C 29H 31N 7O·CH 4SO 3. Its molecular weight is 589.72.
KeywordsChronic Myeloid Leukemia Gastrointestinal Stromal Tumor Blast Crisis Chronic Myeloid Leukemia Cell Central Nervous System Relapse
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- Hughes TP, Hochhaus A, Branford S et al (2010) Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood 116:3758–3765CrossRefPubMedPubMedCentralGoogle Scholar
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