Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Stem-Like Cancer Cells

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5495-2

Synonyms

Definition

Cancer stem cells (CSC) are functional rather than having a fixed definition. The least stringent definition would be that the prospectively purified CSC population is more tumorigenic than the bulk or the marker-negative tumor cell population(s) in a suitable tumor development assay. Using the most stringent definition, a cancer stem cell should be a cell that, at the single-cell level, can reconstitute, in a recipient animal, a tumor that is identical to the parental patient tumor and that can be serially xenotransplanted indefinitely. Therefore, in a strict sense, none of the CSC thus far reported can be truly classified as CSC and should more appropriately be called tumor-reinitiating cells. In reality, it will be very difficult to identify a tumorigenic cell that can fulfill the most stringent definition of a cancer...

Keywords

Cancer Stem Cell Side Population Side Population Cell Normal Stem Cell Mammary Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Carcinogenesis, Science Park-Research DivisionThe University of Texas M. D Anderson Cancer CenterSmithvilleUSA