Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Staurosporine

  • Molliane Mcgahren-Murray
  • Khandan Keyomarsi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5484-2

Definition

Staurosporine is a natural product originally isolated from the bacterium Streptomyces staurosporeus from a soil sample obtained in Japan (Iwate Prefecture) in 1977 during a search for new alkaloids present in actinomycetes and given the name AM-2282. The term alkaloid refers to a naturally occurring amine produced either by a plant, animal, or fungus. Actinomycetes are a group of Gram-positive bacteria that had previously been shown to produce the alkaloids pyrindicin, NA-337A, and TM-64.

Characteristics

The initial studies on AM-2282 focused on the taxonomy of the producing strain, fermentation, isolation, and physicochemical and biological properties of this new alkaloid. Besides being identified as a new species, they also discovered that AM-2282 had antimicrobial activity. The term antimicrobial is given to any type of chemical compound that can suppress the growth of, or aid in the death of, microorganisms, such as bacteria, yeast, and mycoplasma. AM-2282 had...

Keywords

Melanoma Cell Line Myosin Light Chain Kinase Chicken Embryo Fibroblast Rous Sarcoma Virus Insulin Receptor Tyrosine Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Furusaki A, Hahiba H, Matsumoto T et al (1978) X-ray crystal structure of staurosporine: a new alkaloid from a Streptomyces strain. J Chem Soc Chem Commun 18:800–801CrossRefGoogle Scholar
  2. Link JT, Raghavan S, Gallant M et al (1996) Staurosporine and ent-staurosporine: the first total syntheses, prospects for a regioselective approach, and activity profiles. J Am Chem Soc 118:2825–2842CrossRefGoogle Scholar
  3. Sausville EA et al (2001) Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms. J Clin Oncol 19(8):2319–2333PubMedGoogle Scholar
  4. Tamaoki T et al (1986) Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinase. Biochem Biophys Res Commun 135(2):397–402CrossRefPubMedGoogle Scholar
  5. Zhang XD, Gillespie SK, Hersey P (2004) Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Mol Cancer Ther 3(2):187–197PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Molliane Mcgahren-Murray
    • 1
  • Khandan Keyomarsi
    • 2
  1. 1.Department of Systems BiologyUnit 1058, University of Texas, MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Experimental Radiation OncologyUnit 1052, University of Texas, MD Anderson Cancer CenterHoustonUSA