Snail Transcription Factors
Additional synonyms for Snail1: Snail: SnR (chick), SNAILH (human), and Sna.
Additional synonyms for Snail2: Slug, hSlug (human), Xslug (Xenopus), Slugh (mouse), and Slu.
Human symbols for Snail1 and Snail2: SNAI1 and SNAI2.
Snail-like and SNAILP both refer to a human-specific Snail1 retrogene inserted in chromosome 2.
Snail genes are zinc finger transcriptional regulators of the Snail gene superfamily that participate in developmental and pathological epithelial-mesenchymal transition (EMT) processes. Snail1 was initially characterized as a potent repressor of E-cadherin, a major anti-invasive molecule in carcinomas. Snail1 is thus proposed as a potent inductor of tumor invasion, a process that frequently occurs associated with EMT. Besides E-cadherin repression, Snail1-mediated EMT requires the set in motion of a complex genetic program leading to the downregulation of additional epithelial gene markers, the upregulation of mesenchymal and migratory...