Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Slit

  • Tamra E. Werbowetski-Ogilvie
  • Mohamad Seyed Sadr
  • Rolando F. Del Maestro
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DOI: https://doi.org/10.1007/978-3-642-27841-9_5351-2
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Definition

The Slit family of secreted proteins has been shown to function in axon guidance and neuronal migration. There are three Slit proteins in mammals, and while Slit1 expression is mostly restricted to the nervous system, Slit2 and Slit3 are also expressed in other organs.

Characteristics

A typical Slit protein contains an N-terminal signal peptide, four leucine-rich repeats (LRRs), seven (in Drosophila) or nine (in vertebrates) EGF repeats, a laminin G domain, and a C-terminal cysteine knot (Fig. 1). The receptor for Slit is the transmembrane protein Robo (Roundabout), and four ROBO genes have been identified. Typically, Robo proteins, including Robo1, consist of five extracellular immunoglobulin (Ig) domains, three fibronectin repeats, and a conserved intracellular region of four cytoplasmic motifs (Fig. 1).

Keywords

Growth Cone Axon Guidance Medulloblastoma Cell External Granular Layer Commissural Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Dickson BJ (2002) Molecular mechanisms of axon guidance. Science 298:1959–1964CrossRefPubMedGoogle Scholar
  2. Dickson BJ, Gilestro GF (2006) Regulation of commissural axon pathfinding by slit and its robo receptors. Annu Rev Cell Dev Biol 22:651–675CrossRefPubMedGoogle Scholar
  3. Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N et al (2006) Inhibition of medulloblastoma cell invasion by Slit. Oncogene 25:5103–5112PubMedPubMedCentralGoogle Scholar
  4. Wong K, Park HT, Wu JY et al (2002) Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev 12:583–591CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Axon Guidance. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 324. doi: 10.1007/978-3-642-16483-5_497Google Scholar
  2. (2012) Glioblastoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1554. doi: 10.1007/978-3-642-16483-5_2421Google Scholar
  3. (2012) Risk Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3310. doi: 10.1007/978-3-642-16483-5_5111Google Scholar
  4. (2012) Robo. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3316. doi: 10.1007/978-3-642-16483-5_5119Google Scholar
  5. (2012) SrGAPs. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3499. doi: 10.1007/978-3-642-16483-5_5475Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Tamra E. Werbowetski-Ogilvie
    • 1
  • Mohamad Seyed Sadr
    • 2
  • Rolando F. Del Maestro
    • 2
  1. 1.Regenerative Medicine Program, Biochemistry and Medical Genetics and Physiology and Pathophysiology, College of Medicine, Faculty of Health SciencesUniversity of ManitobaWinnipegCanada
  2. 2.MontrealCanada