Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

BARD1

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_526-2

Synonyms

Definition

BARD1 codes for a protein that forms a functional heterodimer with the breast cancer predisposition gene product BRCA1. The BRCA1-BARD1 complex has E3 ubiquitin ligase activity, but not the respective monomers. The specific targets of the BRCA1-BARD1 ubiquitin ligase partially explain the tumor suppressor functions of BARD1 and BRCA1. BRCA1-independent functions are attributed to BARD1, based on its role as inducer of p53-dependent apoptosis. Cancer cells and human cytotrophoblasts express isoforms of BARD1 that lack various functional regions, are void of tumor suppressor functions, and have tumor promoting activities (Irminger-Finger et al. 2015).

Characteristics

The tumor suppressor BARD1 was originally identified as a protein binding to the BRCA1 gene product, BRCA1. The stability of both proteins depends on their interaction via their N-terminal RING finger domains. BRCA1 depends on binding to BARD1 for...

Keywords

Ring Finger Tumor Suppressor Function Differential Splice Ubiquitin Ligase Activity Ring Finger Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bosse KR, Diskin SJ, Cole KA, Wood AC, Schnepp RW, Norris G, Nguyen LB, Jagannathan J, Laquaglia M, Winter C et al (2012) Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer Res 72:2068CrossRefPubMedPubMedCentralGoogle Scholar
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  3. Feki A, Jefford CE, Durand P, Harb J, Lucas H, Krause KH, Irminger-Finger I (2004) BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated. Biol Reprod 71:1614–1624CrossRefPubMedGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and ObstetricsGeneva University HospitalsGenevaSwitzerland