Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Renal Cancer Genetic Syndromes

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_5022-2

Synonyms

Definition

Renal carcinoma is a cancer, arising from the epithelial cells of the kidney, and must be distinguished from tumors of the renal pelvis.

Characteristics

Worldwide, about 150,000 people develop renal carcinoma each year, and ~78,000 individuals die from the disease. Most cases of renal carcinoma are sporadic, that is, most renal carcinomas occur without an inherited predisposition to develop renal cancer. About 1–5 % of renal carcinomas are the consequence of an inherited tendency to develop renal cancer.

Cigarette smoke (Tobacco Carcinogenesis) is a recognized environmental factor that can lead to renal cancer. Exposure to high doses of trichloroethylene, an industrial solvent, may also lead to renal cancer. Renal tumors occur more commonly in men than woman. The male/female ratio for renal cancer is about 2/1.

Early Diagnosis

Currently, there are no accepted methods for the early renal cancer diagnosis. Although...

Keywords

Cell Renal Carcinoma Renal Tumor Renal Cancer Renal Carcinoma Clear Cell Renal Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Hutson TE, Figlin RA, Kuhn JG, Motzer RJ (2008) Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 13:1084–1096CrossRefPubMedGoogle Scholar
  2. Kovacs G (1993) Molecular cytogenetics of renal cell tumors. Adv Cancer Res 62:89–124CrossRefPubMedGoogle Scholar
  3. Larkin JMG, Chowdhury S, Gore ME (2007) Drug insight: advances in renal cell carcinoma and the role of targeted therapies. Nat Clin Pract Oncol 4:470–479CrossRefPubMedGoogle Scholar
  4. Linehan WM, Yang JC, Bates SE (2004) Cancer of the kidney. In: DeVita SE, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 7th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  5. Lubensky IA, Schmidt L, Zhuang Z et al (1999) Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. Am J Pathol 155:517–516CrossRefPubMedPubMedCentralGoogle Scholar
  6. Reddan DN, Raj GV, Polascik TJ (2001) Management of small renal tumors: an overview. Am J Med 110(7):558–562CrossRefPubMedGoogle Scholar
  7. Zbar B, Lerman M (1998) Inherited carcinomas of the kidney. Adv Cancer Res 75:164–201Google Scholar

See Also

  1. (2012) Fibrofolliculoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1398. doi:10.1007/978-3-642-16483-5_6504Google Scholar
  2. (2012) Founder Effect. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1446–1447. doi:10.1007/978-3-642-16483-5_6505Google Scholar
  3. (2012) Hypermethylation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1784. doi:10.1007/978-3-642-16483-5_2910Google Scholar
  4. (2012) Missense Mutation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2330. doi:10.1007/978-3-642-16483-5_3761Google Scholar
  5. (2012) Nonsense Mutation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2546. doi:10.1007/978-3-642-16483-5_4124Google Scholar
  6. (2012) Renal Oncocytoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3252. doi:10.1007/978-3-642-16483-5_6507Google Scholar
  7. (2012) Tyrosine Kinase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3822. doi:10.1007/978-3-642-16483-5_6079Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Laboratory of ImmunobiologyNIH – FrederickFrederickUSA