Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Proteomics

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4821-2

Definition

Proteomics is any systematic large scale study of a proteome or subproteome. The term proteome was coined in the mid-1990s as a linguistic equivalent to the concept of the genome. It refers to the complete set of proteins present in a biological specimen such as a single cell organism, a cell line, tissue, or biological fluid (serum, urine, saliva, etc.). The proteomes of complex organisms are far more complex than the set of expressed genes because genes are usually alternatively spliced and expressed proteins are often extensively and heterogeneously posttranslationally modified. Unlike a genome that is largely static over the lifetime of a cell or organism, proteomes are constantly changing in response to changes in the environment of the cell, tissue, or organism. Hence terms such as the “human proteome” or even the proteome of a cell line in tissue culture are meaningless because there are an essentially infinite number of proteomes.

Characteristics

Because many...

Keywords

Shotgun Proteomics Current Analytical Method Shotgun Proteomics Analysis High Resolution Separation Heavy Stable Isotope 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Abbott A (1999) Proteomics, transcriptomics: what’s in a name? Nature 402:715–720CrossRefPubMedGoogle Scholar
  2. Feng J, Shang S, Beretta L (2006) Proteomics for the early detection and treatment of hepatocellular carcinoma. Oncogene 25:3810–3817CrossRefPubMedGoogle Scholar
  3. Garcia-Foncillas J, Bandres E, Zarate R et al (2006) Proteomic analysis in cancer research: potential application in clinical use. Clin Transl Oncol 8(4):250–260CrossRefPubMedGoogle Scholar
  4. Speicher D, Lee K, Tang H et al (2004) Current challenges in proteomics; mining low abundance proteins and expanding protein profiling capacities. In: Ashcroft A, Brenton G, Monaghan J (eds) Advances in mass spectrometry, vol 16. Elsevier B.V, Amsterdam, pp 37–57Google Scholar

See Also

  1. (2012) Biomarkers. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 408–409. doi:10.1007/978-3-642-16483-5_6601Google Scholar
  2. (2012) Proteomic techniques. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3100. doi:10.1007/978-3-642-16483-5_4820Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.The Wistar InstitutePhiladelphiaUSA