Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Prolactin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4765-3

Synonyms

Definition

Prolactin is a 23 kDa protein hormone secreted by the anterior pituitary gland in many species. Although it has many reported biological activities, prolactin’s most noted effects pertain to mammary gland differentiation and promotion of lactation.

Characteristics

Pituitary Prolactin Secretion and Its Regulation

The pituitary gland is located at the base of the brain and is composed of two parts – anterior and posterior. The posterior pituitary is an extension of brain tissue from the hypothalamus and secretes hormones such as vasopressin, which are synthesized in the hypothalamus. The anterior pituitary arises from nonneural tissue and during embryology migrates to a position anterior to the posterior pituitary. The anterior pituitary is connected to the hypothalamus by a network of blood vessels that run with the neural “stalk” connecting the posterior pituitary to the hypothalamus. This...

Keywords

Dopamine Agonist Anterior Pituitary Ergot Alkaloid Prolactin Secretion Posterior Pituitary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Clevenger CV, Furth PA, Hankinson SE et al (2003) The role of prolactin in mammary carcinoma. Endocr Rev 24:1–27CrossRefPubMedPubMedCentralGoogle Scholar
  2. Gillam MP, Molitch ME, Lombardi G et al (2006) Advances in the treatment of prolactinomas. Endocr Rev 27:485–534CrossRefPubMedGoogle Scholar
  3. Rui H (2000) Prolactin. In: Oppenheim JJ, Feldman M (eds) Cytokine reference on-line. Academic/Harcourt, London, pp 267–283Google Scholar
  4. Schlechte JA (2003) Clinical practice. Prolactinoma. N Engl J Med 349:2035–2041CrossRefPubMedGoogle Scholar
  5. Serri O, Chik CL, Ur E et al (2003) Diagnosis and management of hyperprolactinemia. Can Med Assoc J 169:575–581Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, UAB, Endocrinology Section, Birmingham VAMC Medical ServiceBirmingham VA Medical Center, University of AlabamaBirminghamUSA