Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Progestin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4756-2

Synonyms

Definition

Progestin is a synthetic progestogen that has progestinic effects similar to progesterone. Progesterone (4-pregnene-3,20-dione, P4) is an ovarian steroid hormone that plays a key role in the regulation of cell proliferation and differentiation in the female reproductive tract. Progesterone also regulates diverse biological effects in a broad range of tissues, even of the cardiovascular and the central nervous systems, and participates in the bone maintenance and regulation of thymic involution. Progesterone has also been implicated in the development and progression of breast cancer. Progestogen defines the category of hormone molecules (natural and synthetic) that act like progesterone in the uterus, and the term progestin has been generally used to refer to both a series of synthetic hormone molecules and progesterone. The generic term progestin refers to both progesterone and synthetic progestins.

Characteristics

The two most studied progesterone...

Keywords

Mammary Gland Progesterone Receptor T47D Cell Nongenomic Effect Breast Cancer Cell Line T47D 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Edwards DP (2005) Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol 67:335–376CrossRefPubMedGoogle Scholar
  2. Jacobsen BM, Richer JK, Sartorius CA et al (2003) Expression profiling of human breast cancers and gene regulation by progesterone receptors. J Mammary Gland Biol Neoplasia 8:257–268CrossRefPubMedGoogle Scholar
  3. Lange CA (2004) Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word? Mol Endocrinol 18:269–278CrossRefPubMedGoogle Scholar
  4. Li X, Lonard DM, O’Malley BW (2004) A contemporary understanding of progesterone receptor function. Mech Ageing Dev 125:669–678CrossRefPubMedGoogle Scholar
  5. Moore NL, Narayanan R, Weigel NL (2007) Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity. Steroids 72:202–209CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Laboratory of Molecular Mechanisms of Carcinogenesis, Institute of Biology and Experimental Medicine (IBYME)CONICETBuenos AiresArgentina