Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Photodynamic Therapy

  • Tobias Kiesslich
  • Kristjan Plaetzer
  • Barbara Krammer
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4553-4

Synonyms

Definition

Photodynamic therapy (PDT) uses the action of visible, low energetic light on a photosensitizer to activate its cytotoxic potential in a target tissue. PDT is a selective treatment modality since the photosensitizer shows preferential accumulation in target (e.g., tumor) cells and the light application can be restricted to the treatment area. By light activation, the photosensitizer forms cytotoxic compounds, mainly reactive oxygen species (ROS), thus destroying the target. The emission of fluorescence light is employed in fluorescence diagnosis for tumor diagnosis and fluorescence-guided surgical resection. PDT is applied for malignant and several nonmalignant diseases.

Characteristics

Historical Perspective

In 1904, the term “photodynamic” was coined for light-induced cytotoxic action and fluorescence of a photosensitizer. Modern PDT started in the 1970s with the investigation and usage of hematoporphyrin...

Keywords

Genital Herpes Photodynamic Inactivation Deoxy Adenosine Triphosphate Blood Flow Stasis Photodynamic Tumor Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Agostinis P, Berg K, Cengel KA et al (2011) Photodynamic therapy of cancer: an update. CA Cancer J Clin 61:250–281CrossRefPubMedPubMedCentralGoogle Scholar
  2. Dolmans DE, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3:380–387CrossRefPubMedGoogle Scholar
  3. Kiesslich T, Tortik N, Pichler M et al (2013) Apoptosis in cancer cells induced by photodynamic treatment – a methodological approach. J Porphyrins Phthalocyanines 17:197–209CrossRefGoogle Scholar
  4. Plaetzer K, Kiesslich T, Oberdanner CB et al (2005) Apoptosis following photodynamic tumor therapy: induction, mechanisms and detection. Curr Pharm Des 11:1151–1165CrossRefPubMedGoogle Scholar
  5. Triesscheijn M, Baas P, Schellens JH et al (2006) Photodynamic therapy in oncology. Oncologist 11:1034–1044CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Tobias Kiesslich
    • 1
  • Kristjan Plaetzer
    • 2
  • Barbara Krammer
    • 3
  1. 1.Department of Internal Medicine I, Paracelsus Medical University, Institute of Physiology and PathophysiologyParacelsus Medical UniversitySalzburgAustria
  2. 2.Laboratory of Photodynamic Inactivation of Microorganisms, Division of Physics and BiophysicsUniversity of SalzburgSalzburgAustria
  3. 3.Department of Molecular BiologyUniversity of SalzburgSalzburgAustria