Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatic Cancer: Molecular Targets for Therapy

  • Steven N. Hochwald
  • William G. Cance
  • Elena Kurenova
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4358-4

Definition

Pancreatic cancer, synonym pancreas cancer, is a virulent disease with no effective therapy besides surgical resection. The possibility for surgical tumor removal is limited by early metastatic spread of tumor to sites outside the pancreas. The survival for patients with metastatic pancreatic cancer is less than 1 year following diagnosis. Clinicians must translate the available knowledge of the molecular basis of this disease into rationale and effective therapeutic strategies for treatment.

Pancreas cancer is one of the tumors with the highest number of genetic mutations of any solid malignancy. These include oncogenes, tumor suppressor genes, and DNA-stability genes. The stability genes include mismatch repair (MMR) and base excision repair (BER) genes, which control the mutation rate of other genes. A number of genetic alterations have been, and still are being, tested as molecular target for antipancreatic cancer therapy. It is clear that novel molecular targets and...

Keywords

Epidermal Growth Factor Receptor Pancreatic Cancer Focal Adhesion Kinase Pancreatic Cancer Cell Pancreatic Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Steven N. Hochwald
    • 1
  • William G. Cance
    • 1
  • Elena Kurenova
    • 1
  1. 1.Departments of Surgical OncologyRoswell Park Cancer InstituteBuffaloUSA