Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Aspirin

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DOI: https://doi.org/10.1007/978-3-642-27841-9_415-12
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Synonyms

2-Acetoxybenzenecarboxylic acid; 2-Acetoxybenzoic acid; Acetylsalicylic acid; Empirin; Salicylate

Definition

Is a trademarked name of a specific preparation of acetylsalicylic acid. It is a nonsteroidal anti-inflammatory drug (NSAID) and used as pain reliever and fever reducer.

Characteristics

Salicylic acid was originally found in the bark of the white willow. Use of willow bark as pain reliever dates back as far as Hippocrates when it was administered to patients by chewing the bark of white willow to extract effective ingredient. In1829, scientists discovered that this effective ingredient was the compound called salicin. Later, this ingredient was extracted and combined with a buffering agent to form acetylsalicylic acid (acetylated derivative of salicylic acid). In 1899, Bayer claimed to discover aspirin and marketed it worldwide. Aspirin is one of the safest and least expensive pain-killer on the marketplace.

Aspirin has been used as an anti-inflammatory agent for the...

Keywords

Salicylic Acid Esophageal Cancer Colorectal Adenoma Aberrant Crypt Focus Anticancer Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bosetti C, Gallus S, La Vecchia C (2006) Aspirin and cancer risk: an updated quantitative review to 2005. Cancer Causes Control CCC 17:871–888PubMedCrossRefGoogle Scholar
  2. Harris RE, Beebe-Donk J, Doss H, Burr Doss D (2005) Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). Oncol Rep 13:559–583PubMedGoogle Scholar
  3. Kashfi K, Rigas B (2005) Molecular targets of nitric-oxide-donating aspirin in cancer. Biochem Soc Trans 33:701–704PubMedCrossRefGoogle Scholar
  4. Reddy BS, Rao CV, Rivenson A, Kelloff G (1993) Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 14:1493–1497PubMedCrossRefGoogle Scholar

See Also

  1. (2012) Acetylsalicylic Acid. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 17. doi: 10.1007/978-3-642-16483-5_26Google Scholar
  2. (2012) Arachidonic Acid. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 260. doi: 10.1007/978-3-642-16483-5_379Google Scholar
  3. (2012) Beta-Catenin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 385. doi: 10.1007/978-3-642-16483-5_889Google Scholar
  4. (2012) Bradykinin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 468. doi: 10.1007/978-3-642-16483-5_701Google Scholar
  5. (2012) Epithelial Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1291–1292. doi: 10.1007/978-3-642-16483-5_1958Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Nutrition and Food ScienceUniversity of MarylandCollege ParkUSA