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Encyclopedia of Cancer pp 1–7Cite as

Non-Small-Cell Lung Cancer

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Definition

Advanced non-small-cell lung cancer (NSCLC) is a dismal disease, though outcomes can be improved when cisplatin treatment is customized on the basis of gene expression profiling. In addition, patients with epidermal growth factor receptor (EGFR) mutations attain a 70 % response and prolonged survival to targeted therapies, but drug resistance can be mediated by expression of DNA repair genes, including expression of the breast cancer susceptibility gene 1 (BRCA1).

Two treatment approaches for advanced NSCLC patients can be carried out in large clinical trials of treatment customized by molecular analyses:

  • For patients without EGFR mutations, personalized chemotherapy based on the BRCA1-receptor associated protein 80 (RAP80)

  • For patients with EGFR mutations, EGFR tyrosine kinase inhibitors (TKIs) plus EGFR T790M inhibitors or individualized chemotherapy based on BRCA1 mRNA levels

Characteristics

Survival Rates

The median survival of patients with advanced or metastatic NSCLC...

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References

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Author information

Authors and Affiliations

  1. Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Barcelona, Spain

    Rafael Rosell

  2. Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain

    Delvys Rodriguez-Abreu

Authors
  1. Rafael Rosell
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  2. Delvys Rodriguez-Abreu
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Corresponding author

Correspondence to Rafael Rosell .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Rosell, R., Rodriguez-Abreu, D. (2014). Non-Small-Cell Lung Cancer. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4119-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_4119-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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