Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Nek2

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4001-2

Definition

NIMA-related kinase 2; Nek2 is a cell cycle-regulated, intracellular protein kinase that contributes to passage of cells through mitosis. Its upregulation in a number of cancer types has raised the possibility that its expression level is important to normal cell division and that it might make a novel cell cycle target for cancer therapy.

Characteristics

Nek2 is a ubiquitously expressed, serine/threonine protein kinase. It localizes to the centrosome and functions in cell cycle control contributing to the correct assembly of the bipolar mitotic spindle upon which chromosomes are segregated. As such, Nek2 belongs to a small group of important protein kinases, including CDK1, Plk1, and Aurora A, that are centrosomal and regulate structural aspects of mitosis. Elevated levels of Nek2 have been detected in a number of human cancer types and cancer-derived cell lines raising the possibility that deregulated Nek2 may contribute to aspects of the disease such as aneuploidy and chro...

Keywords

Spindle Assembly Checkpoint Bipolar Spindle Mitotic Entry Duplicate Centrosome Meiotic Cell Division 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Fry AM (2002) The Nek2 protein kinase: a novel regulator of centrosome structure. Oncogene 21:6184–6194PubMedCrossRefGoogle Scholar
  2. Hayward DG, Fry AM (2006) Nek2 kinase in chromosome instability and cancer. Cancer Lett 237:155–166PubMedCrossRefGoogle Scholar
  3. O’Connell MJ, Krien MJ, Hunter T (2003) Never say never. The NIMA-related protein kinases in mitotic control. Trends Cell Biol 13:221–228PubMedCrossRefGoogle Scholar
  4. Quarmby LM, Mahjoub MR (2005) Caught Nek-ing: cilia and centrioles. J Cell Sci 118:5161–5169PubMedCrossRefGoogle Scholar

See Also

  1. (2012) Mitosis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2342. doi:10.1007/978-3-642-16483-5_3774Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of LeicesterLeicesterUK