Arginine-Depleting Enzyme Arginine Deiminase
To starve cancer cells through amino acid deprivation can be a strategy in cancer therapy. Specific amino acids are required for the growth of certain tumor cells, while normal cells can synthesize sufficient amounts for their own needs. For example, an enzyme called asparaginase has been used to deplete asparagine in the treatment of acute lymphoblastic leukemia and a few subtypes of non-Hodgkin lymphoma (Malignant Lymphoma, Hallmarks and Concepts) because these cancers lack asparagine synthetase and are auxotrophic for asparagine. Asparaginase degrades both asparagine and glutamine. The antitumor activity of this enzyme is due to its ability to degrade asparagine, and some of its deleterious side effects were due to its degradation of glutamine.
ADI is an enzyme that hydrolyzes arginine to...