Motility is a cellular function that leads to the translocation of the cell body through a coordinated sequence of distinct biological processes, including membrane protrusion at a leading edge, the formation of cell-substrate adhesion, the development of contractile force in the cell body, and detachment at the tail of the cell.
Cell motility is a critical feature of various physiological and pathological processes, such as development, wound healing, immunity, angiogenesis, invasion, and metastasis. It includes chemokinesis (nondirectional movement) and chemotaxis (directional movement). Cell motility is generally triggered by extracellular stimuli such as gradients of chemotactic factors. In the presence of chemoattractants, extracellular signals are transduced through cell-surface receptors which thus induce various intracellular responses, such as the polarization and reorganization of the actin...