Molecular pathology is the study of the molecular genetic causes of abnormal cell and tissue functioning with the goal of improved disease diagnosis and treatment. As a medical discipline, molecular pathology is a specialty training that incorporates the subject matter of genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, and laboratory management and impacts both anatomic and clinical pathology practice.
Historical and Clinical Background
Pathology, the study of the origin, nature, and courses of diseases, has its foundation in the studies of Giovanni Battista Morgagni of Padua (1682–1771) (the “father of anatomic pathology”) and Rudolf Virchow of Berlin (1821–1902) (the “father of cellular pathology”). Dr. Morgagni documented the relationship between diseases and the gross changes observed in autopsy specimens, and Dr. Virchow established the correlation of...