Mastocytosis, a hematopoietic neoplasm, is a clonal disorder of the mast cell and its progenitor resulting in the presence of excessive numbers of mast in the skin, bone marrow, and internal organs such as the liver, spleen, and lymph nodes.
Most patients with mastocytosis present with symptoms due to the release of mediators from activated mast cells in various tissues. The activation of mast cells can be caused by triggers such as temperature changes, emotional or physical stress, exercise, ingestion of alcohol, spicy foods, or mast cell degranulating drugs, insect venom, and allergens, but may also occur without an apparent stimulus. Patients with mastocytosis display a wide range of clinical presentations, ranging from no symptoms to severe life-threatening syncopal episodes or hematologic abnormalities. The most common symptoms of mast cell degranulation are itching, flushing, gastrointestinal symptoms such as heartburn and diarrhea, lightheadedness, and...
KeywordsMast Cell Systemic Mastocytosis Tryptase Level Urticaria Pigmentosa Mast Cell Leukemia
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