Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

APAF-1 Signaling

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_345-2

Synonyms

Definition

APAF-1 was identified in 1997 as a homolog of C. elegans cell death 4 (CED-4) gene. APAF-1 is a cytoplasmatic protein of 1194 aminoacids able to bind cytochrome-c and contributing to caspase-9 activation. APAF-1 protein exists in cells in an inactive monomeric form. Signals that activate the intrinsic pathway of apoptosis (such as developmental cues, genomic stress, endoplasmic reticulum stress, cytotoxic damage, hypoxia, growth factor deprivation, and cell detachment) lead to mitochondria outer membrane permeabilization (MOMP). As a result of MOMP, cytochrome-c, a component of the mitochondrial respiratory chain, present in the intermembrane space, is released from mitochondria into the cytosol, where it binds to APAF-1. Upon binding of cytochrome-c, in the presence of dATP/ATP, APAF-1 undergoes a conformational change....

Keywords

Burkitt Lymphoma Betulinic Acid Allelic Imbalance Mitochondrion Outer Membrane Permeabilization APAF1 Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Experimental OncologyFondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei TumoriMilanItaly