Lunasin is a naturally occurring peptide found in soybean and other plants with potent chemopreventive properties against different types of cancer.
Lunasin (from the Tagalog word “lunas” for cure) is a 43-amino acid peptide initially identified in the soybean cotyledon (Galvez and de Lumen 1999). It corresponds to the small subunit peptide encoded within the soybean 2S albumin Gm2S-1 gene that also codes for a methionine-rich protein, a signal peptide, and a linker peptide. The sequence of lunasin 1SKWQHQQDSCRKQLQGVNLTPC22-23EKHIMEKIQG32-33RGD35-DDDDDDDD43(National Center for Biotechnology Information, NCBI, accession number AAP62458) is composed of four regions: fragment f(1–22) without any known function yet, f(23–32) targeting lunasin to chromatin, f(33–35) corresponding to RGD cell adhesion motif internalizing lunasin into the cell nucleus, and a continuous sequence f(35–43) of nine aspartic acid (D) residues responsible for lunasin’s direct binding to...
KeywordsSodium Butyrate Anacardic Acid Kunitz Trypsin Inhibitor Colorectal Cancer Liver Metastasis Decrease Reactive Oxygen Species Level
Family of proteins that control the progression of cells through the cell cycle by activating CDK enzymes.
Family of protein kinases with molecular weights ranged from 34 to 40 kDa, present in all known eukaryotics, that bind a regulatory protein called cyclin. They are involved in the regulation of cell cycle, transcription, mRNA processing, and differentiation of nerve cells.
Study, in the field of genetics, of cellular and phenotypical variations caused by external or environmental factors that switch genes on and off affecting the mode how cells “read” genes. Epigenetic research describes dynamic alterations in the transcriptional potential of a cell.
Highly alkaline proteins found in the nucleus of eukaryotic cells responsible for packaging and ordering the DNA into structural units called nucleosomes. They are the chief protein components of chromating, playing a crucial role in gene regulation.
Human phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase encoded by the PTEN gene. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-triphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.
Tumor suppressor protein belonging to the pocket protein family whose members have a pocket for the functional binding of other proteins. One of its major functions is the prevention of excessive cell growth by inhibiting cell cycle progression until the cell is ready to divide. When the cell is ready, Rb is phosphorylated, becoming inactive, thus allowing cell cycle progression. It also acts as a recruiter of several chromatin-remodeling enzymes such as methylases and acetylases.
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