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Log-Kill Hypothesis

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 72 Accesses

Synonyms

Skipper-Schabel model; Skipper-Schabel-Wilcox model

Definition

The log-kill hypothesis proposes a model for the effect of cytotoxic chemotherapy on tumor size. It states that a given dose of chemotherapy kills the same fraction of tumor cells regardless of the size of the tumor at the time of treatment.

Characteristics

Experimental and mathematical models have attempted to describe the fundamentals of tumor cell growth and kinetics. From these systems arose an improved understanding of tumor growth characteristics, a foundation for the key principles of chemotherapy, and, eventually, recognition of the importance of dose scheduling. The Skipper-Schabel-Wilcox model is one of the most influential and pioneering experiments in the history of oncology.

Investigators at the Southern Research Institute developed a simple model of tumor growth using L1210 murine leukemia cells. This system had two notable features: a seemingly exponential growth pattern and the ability to...

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References

  • Chu E, DeVita V (2005) Principles of medical oncology. In: DeVita V, Hellman S, Rosenberg S (eds) Cancer principles and practice of oncology. Lippincott Williams and Wilkins, Philadelphia, pp 295–301

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  • Gilewski T, Dang C, Surbone A et al (2003) Cytokinetics. In: Holland J, Frei E (eds) Cancer medicine, 6th edn. BC Decker, Hamilton

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  • Traina TA, Hudis C, Norton L (2006) Dose-dense chemotherapy for breast cancer: a validation of the Norton-Simon hypothesis. In: De Vita VT Jr, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology updates. Lippincott Williams and Wilkins, Philadelphia. Chap 8

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See Also

  • (2012) Gompertzian Growth Curve. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1576. doi:10.1007/978-3-642-16483-5_2473

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Author information

Authors and Affiliations

  1. Breast Cancer Medicine Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Tiffany A. Traina & Larry Norton

Authors
  1. Tiffany A. Traina
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  2. Larry Norton
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Corresponding author

Correspondence to Tiffany A. Traina .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Traina, T.A., Norton, L. (2015). Log-Kill Hypothesis. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3409-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_3409-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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