The log-kill hypothesis proposes a model for the effect of cytotoxic chemotherapy on tumor size. It states that a given dose of chemotherapy kills the same fraction of tumor cells regardless of the size of the tumor at the time of treatment.
Experimental and mathematical models have attempted to describe the fundamentals of tumor cell growth and kinetics. From these systems arose an improved understanding of tumor growth characteristics, a foundation for the key principles of chemotherapy, and, eventually, recognition of the importance of dose scheduling. The Skipper-Schabel-Wilcox model is one of the most influential and pioneering experiments in the history of oncology.
Investigators at the Southern Research Institute developed a simple model of tumor growth using L1210 murine leukemia cells. This system had two notable features: a seemingly exponential growth pattern and the ability to...
KeywordsAdjuvant Therapy Early Stage Cancer Postoperative Setting Sensitive Population Pioneer Experiment
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