Lobular Involution of the Breast
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Involution refers to a progressive decrease in the size of an organ usually associated with a decline in function. Organs that undergo involution include the postpartum uterus, the ovaries after menopause, the thymus gland, and the milk-producing lobular structures of the breast. Except for the postpartum uterus, involutional changes are regarded as a manifestation of aging and are often irreversible.
Anatomy of the Human Breast
Although variable, the adult human female breast, in general, consists of 15–20 irregular lobes that are separated by layers of connective tissue as they fan out from the nipple into the mammary gland proper. These lobes empty independently into the nipple through the lactiferous ducts, which conduct milk to the nipple. The lactiferous ducts subdivide and terminate in multiple small lobules, which subdivide into multiple glandular acini or alveoli that produce milk during lactation. These lobules...
KeywordsBreast Cancer Breast Cancer Risk Mammographic Density Breast Cancer Risk Factor Reduce Breast Cancer Risk
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- Cowan DF, Herbert TA (1989) Involution of the breast in women aged 50 to 104 years: a histopathological study of 102 cases. Surg Pathol 2:323–333Google Scholar