Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

5-Lipoxygenase

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3390-6

Synonyms

Definition

5-LOX is a nonheme iron dioxygenase that catalyzes the synthesis of a broad class of compounds, known as leukotrienes (LT), lipoxins, resolvins, and protectins.

Characteristics

In human beings, this enzyme is encoded by the Alox5 gene (Chromosome 10, Location 10q11.2).

Its substrates belong to the polyunsaturated fatty acids (PUFAs) family, mainly the ω-3 and ω-6, where 5-LOX inserts O2 in a regional-specific fashion.

From the ω-6 arachidonic acid (AA, 20:4n-6), the proinflammatory LTB4, LTC4, LTD4, LTE4, and lipoxins are formed; the anti-inflammatory LTB5, LTC5, LTD5, LTE5, and E-series resolvins derive from the ω-3 eicosapentaenoic acid (EPA, 20:5n-3); from the ω-3 docosahexaenoic acid (DHA, 22:6n-3), protectins and D-series resolvins are synthesized. Notwithstanding, the inflammatory or anti-inflammatory nature of these compounds is currently under revision, due to emerging contradictory role of 5-LOX products in both...

Keywords

Pulmonary Microvascular Endothelial Cell Human Pulmonary Microvascular Endothelial Cell Vascular Endothelial Growth Factor Induction Breast Cancer Stem Cell Phenotype Human Brain Endothelial Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Banerjee S, Tuncay S (2006) ALOX5 (Arachidonate 5-Lipoxygenase) Atlas of genetics and cytogenetics in oncology and hematology. http://AtlasGeneticsOncology.org/Genes/ALOX5ID42985ch10q11.html
  2. Funk CD, Hoshiko S, Matsumoto T, Radmark O, Samuelsson B (1989) Characterization of the human 5-lipoxygenase gene. Proc Natl Acad Sci U S A 86:2587–2591PubMedCentralCrossRefPubMedGoogle Scholar
  3. Steinhilber D, Fischer AS, Metzner J, Steinbrink SD, Roos J, Ruthardt M, Maier TJ (2010) 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. Front Pharmacol 1:143PubMedCentralCrossRefPubMedGoogle Scholar
  4. Taosheng C (2012) Interleukin-6. Encyclopedia of cancer. (Springer ed.) http://www.springerreference.com/docs/biopage/36365.html
  5. Tavolari S, Bonafè M, Marini M, Ferreri C, Bartolini G, Brighenti E, Manara S, Tomasi V, Laufer S, Guarnieri T (2008) Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 29:371–380CrossRefPubMedGoogle Scholar
  6. Zhang Z, Chen CQ, Manev H (2004) DNA methylation as an epigenetic regulator of neural 5-lipoxygenase expression: evidence in human NT2 and NT2-N cells. J Neurochem 88:1424–1430CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biology, Geology and Environmental SciencesAlma Mater Studiorum University of BolognaBolognaItaly