Kit/Stem Cell Factor Receptor in Oncogenesis
Going from the N terminus toward the C terminus, all RPTKs contain an extracellular ligand-binding domain, a single transmembrane-spanning domain, and an intracellular domain composed of a hydrophilic juxtamembrane (JM) region, followed by the highly conserved tyrosine kinase domain and a hydrophilic C terminus. Based on structural similarities, Kit/SCF-R belongs to the subclass III of RPTKs that includes the receptors for platelet-derived growth factor (PDGF) α and β, colony-stimulating factor-1 (CSF-1), and the Flt-3/Flk-2 RPTK. These proteins are ∼950–1100 amino acids in length, with ∼550...
KeywordsMast Cell Acute Myeloid Leukemia Chronic Myeloid Leukemia Systemic Mastocytosis Acute Myeloid Leukemia Case
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