Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Kallikreins

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3194-2

Synonyms

Definition

Kallikreins are a family of serine proteases encoded by genes clustered on chromosome 19q13.4. Their expression is associated with progression of several cancers, and they serve as biomarkers. Among the kallikreins, prostate-specific antigen (PSA; kallikrein 3, KLK3) is the most well-known kallikrein.

Characteristics

Kallikreins play important roles in cancer development. For several decades, kallikreins have been known as enzymes that generate bioactive peptides, called kinins, involved in blood-pressure regulation. When the first kallikrein (kallikrein 1) was discovered in 1930, the enzyme was reported to have a hypotensive effect and be present at high concentrations in the pancreas, the organ known as kallikreasin Greek. It is now known that kallikrein 1 produces bradykinin from kininogen. Bradykinin is an active peptide of the kinin protein group. It consists of nine amino acid residues and is a potent...

Keywords

Catalytic Triad Urokinase Plasminogen Activator Tissue Kallikrein Plasma Kallikrein Endometrial Cancer Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Avgeris M, Mavridis K, Scorilas A (2010) Kallikrein-related peptidase genes as promising biomarkers for prognosis and monitoring of human malignancies. Biol Chem 391:505–511CrossRefPubMedGoogle Scholar
  2. Borgono CA, Diamandis EP (2004) The emerging roles of human tissue kallikreins in cancer. Nat Rev Cancer 4:876–890CrossRefPubMedGoogle Scholar
  3. Lundwall A, Band V, Blaber M et al (2006) A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem 387:637–641PubMedGoogle Scholar
  4. Petraki CD, Papanastasiou PA, Karavana VN et al (2006) Cellular distribution of human tissue kallikreins: immunohistochemical localization. Biol Chem 387:653–663CrossRefPubMedGoogle Scholar
  5. Yousef GM, Obiezu CV, Luo LY et al (2005) Human tissue kallikreins: from gene structure to function and clinical applications. Adv Clin Chem 39:11–79CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Biomedical SciencesAcademia Sinica TaipeiTaiwanRepublic of China