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JNK Subfamily

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 98 Accesses

Synonyms

c-Jun N-terminal kinase; JNK1; JNK2; JNK3; MAPK10; MAPK8; MAPK9; SAPKα; SAPKβ; SAPKγ; Stress-activated protein kinase

Definition

JNK is an intracellular protein kinase that transmits rapidly and efficiently various different types of signals originating from outside of a cell in the process called signal transduction. Like other protein kinases, JNK is an enzyme that transmits its signals via phosphorylating its specific substrate proteins. The most studied JNK substrate is c-Jun, a component of the dimeric transcription factor AP-1, which gives rise to its name: c-Jun N-terminal kinase. Another name for JNK is a stress-activated protein kinase (SAPK). The p38 MAPKs are also called SAPKs, and thus, the term SAPK actually refers to both JNK and p38 subfamilies.

Characteristics

JNK subfamily consists of three isoforms: JNK1, JNK2, and JNK3. They are encoded by three separate genes: MAPK8, MAPK9, and MAPK10. Alternative splicing of these genes can produce at least ten different...

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References

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See Also

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Authors and Affiliations

  1. Unit of Cell Death and Metabolism, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark

    Tuula Kallunki

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  1. Tuula Kallunki
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Correspondence to Tuula Kallunki .

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Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Kallunki, T. (2015). JNK Subfamily. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3184-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_3184-2

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  • Online ISBN: 978-3-642-27841-9

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