Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

IARC TP53 Database

Living reference work entry
First Online:
Received:
Accepted:
DOI: https://doi.org/10.1007/978-3-642-27841-9_2934-3
How to cite

Definition

The IARC TP53 database is a public Web-based resource for the analysis and interpretation of the biological and clinical impacts of TP53 gene variations in human cancers (http://-p53.iarc.fr/). It contains data manually curated from the scientific literature and public database with information on tumor pathology, patient demographics, and predicted or experimentally assessed functional impacts of mutations. The database can be searched and analyzed with an advanced search interface. The scope of data available can be used to draw hypotheses on the nature of the molecular events involved in TP53 mutagenesis and on the natural history of cancer.

With over 28,000 somatic and 700 germ line mutations and 4000 citations in the world literature, this database is recognized as a major source of information on TP53mutation patterns and phenotypes in human cancers. The database is meant to be a resource for a broad range of scientists and clinicians who work in different research...

Keywords

Germ Line TP53 Mutation TP53 Gene Aristolochic Acid Transactivation Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Hernandez-Boussard T, Montesano R, Hainaut P (1999) Sources of bias in the detection and reporting of p53 mutations in human cancer: analysis of the IARC p53 mutation database. Genet Anal 14:229–233CrossRefPubMedGoogle Scholar
  2. Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a001008CrossRefPubMedPubMedCentralGoogle Scholar
  3. Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, Olivier M (2007) Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 Database. Hum Mutat 28:622–629CrossRefPubMedGoogle Scholar
  4. Vogelstein B, Lane D, Levine AJ (2000) Surfing the p53 network. Nature 408:307–310CrossRefPubMedGoogle Scholar
  5. Vousden KH, Lane DP (2007) p53 in health and disease. Nat Rev Mol Cell Biol. 2007 Apr;8(4):275–83CrossRefPubMedGoogle Scholar

See Also

  1. (2012) CpG. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 990. doi: 10.1007/978-3-642-16483-5_1360Google Scholar
  2. (2012) Missense Mutation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2330. doi: 10.1007/978-3-642-16483-5_3761Google Scholar
  3. (2012) Mutation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2412. doi: 10.1007/978-3-642-16483-5_3911Google Scholar
  4. (2012) Polymorphism. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 2954–2955. doi: 10.1007/978-3-642-16483-5_4673Google Scholar
  5. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331Google Scholar
  6. (2012) SNP. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3460. doi: 10.1007/978-3-642-16483-5_5395Google Scholar
  7. (2012) Tobacco-Related Lung Cancer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3722. doi: 10.1007/978-3-642-16483-5_5849Google Scholar
  8. (2012) Ultraviolet Radiation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3841. doi: 10.1007/978-3-642-16483-5_6102Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Group of Molecular Mechanism and BiomarkersInternational Agency for Research on Cancer, World Health OrganizationLyonFrance