Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Histone Acetyltransferases

  • Evangelia A. Koutsogiannouli
  • Wolfgang A. Schulz
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2751-2

Synonyms

Definition

HATs are a family of proteins that acetylate conserved lysine amino acids on histones and other proteins by transferring an acetyl group from acetyl-CoA to lysine to form ε-N-acetyl lysine. Lysine acetylation neutralizes the normally positive charge of histones, thus reducing their affinity towards (negatively charged) DNA which renders DNA more accessible to transcription factors and other processes. Moreover, histone acetylation generates binding sites for specific protein-protein interaction domains.

Characteristics

HAT Families

Histone acetylation is an important epigenetic mechanismperformed by acetyltransferases (HATs) that transfer an acetyl group to the ε-amino group of lysine residues on histone tails and bodies. Neutralization of the lysine positive charge weakens the binding between histones and DNA. This effect favors a relaxed chromatin structure permitting transcription,...

Keywords

Acute Myeloid Leukemia Lysine Residue Histone Acetylation Curcuma Longa Anacardic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  4. Wang C, Tian L, Popov VM et al (2011) Acetylation and nuclear receptor action. J Steroid Biochem Mol Biol 123:91–100PubMedCentralCrossRefPubMedGoogle Scholar
  5. Yang XJ (2004) The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res 32:959–976PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Evangelia A. Koutsogiannouli
    • 1
  • Wolfgang A. Schulz
    • 1
  1. 1.Department of UrologyHeinrich Heine UniversityDüsseldorfGermany