Herpesvirus-Associated Ubiquitin-Specific Protease De-ubiquitinase
The cysteine protease de-ubiquitinase (DUB) herpesvirus-associated ubiquitin-specific protease (HAUSP) has been fairly well characterized in recent years and has emerged as an important component of the p53-Mdm2 signaling pathway.
De-ubiquitinases are specific protease enzymes that catalyze the removal of ubiquitin from substrates by cleaving the isopeptide bond between ubiquitin and substrate. The de-ubiquitination enzyme family (DUBs) falls within two classes of proteases: the metalloproteases and cysteine proteases, though most DUBs fall within the latter. Further classification subdivides the cysteine proteases into four subclasses: ubiquitin C-terminal hydrolases (UCH), ubiquitin-specific proteases (USP), Machado-Joseph disease proteases (MJD), and Otubain proteases (OTU). The MJD and OTU subclasses were more recently identified through a bioinformatics approach. MJD is a rare hereditary...