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Amplified in Breast Cancer 1

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Encyclopedia of Cancer

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Synonyms

AIB1; Coactivator ACTR; NCoA3; Nuclear receptor coactivator 3; p/CIP; p300/CBP-interacting protein; RAC3; Receptor-associated coactivator 3; SRC-3; Steroid receptor coactivator-3; Thyroid hormone receptor activator molecule 1; TRAM-1

Definition

AIB1 is a 160-kDa intracellular protein that enhances gene expression through interacting with nuclear hormone receptors and some other transcription factors and serving as a transcriptional coactivator. The AIB1 gene is amplified and overexpressed in some human breast tumors.

Characteristics

Molecular Structure and Functional Domains

The human AIB1 gene is located in chromosome 20, and it encodes for a 160-kDa intracellular protein with 1402 amino acid residues. AIB1 is a member of the p160 steroid receptor coactivator (SRC) family that also includes SRC-1 and the transcriptional intermediary factor 2 (TIF2). AIB1 contains multiple structural and functional domains (Fig. 1). The N-terminal basic helix-loop-helix/Per-Ah receptor...

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References

  • Anzick SL et al (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277:965–968

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  • Kuang SQ et al (2004) AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res 64:1875–1885

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  • Torres-Arzayus MI et al (2004) High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell 6:263–274

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  • Xu J, Li Q (2003) Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol 17:1681–1692

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  • Xu J et al (2000) The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci USA 97:6379–6384

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Author information

Authors and Affiliations

  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    Jianming Xu

Authors
  1. Jianming Xu
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Corresponding author

Correspondence to Jianming Xu .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Xu, J. (2015). Amplified in Breast Cancer 1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_248-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_248-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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