Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Glutathione S-Transferase

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2441-2

Synonyms

Definition

GSTs refer to a family of Phase 2 detoxification enzymes that catalyze the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds, thereby decreasing their reactivity with cellular macromolecules. This detoxification ability plays a pivotal role in cellular protection from oxidative stresses.

Characteristics

GSTs are divided into three distinct superfamilies: cytosolic, mitochondrial, and membrane-bound microsomal. Microsomal GSTs play a key role in the endogenous metabolism of leukotrienes and prostaglandins. The mammalian cytosolic GSTs are highly polymorphic and could be divided into six classes: alpha (A), mu (M), omega (O), theta (T), sigma (S), and pi (P). Classification is based on sharing greater than 60% identity within a class and focuses mainly on the more highly conserved N-terminal domain that contains a catalytically active tyrosine, cysteine, or serine...

Keywords

Arsenic Trioxide Ethacrynic Acid Matched Normal Tissue GSTT1 Gene Reduce Survival Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Eaton DL, Bammler TK (1999) Concise review of the Glutathione S-transferases and their significance to toxicology. Toxicol Sci 49:156–164CrossRefPubMedGoogle Scholar
  2. Mcllwain CC, Townsend DM (2006) TEW KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy: Oncogene 25:1639–1648Google Scholar
  3. Sheehan D, Meade G, Foley VM et al (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J 360:1–16CrossRefPubMedPubMedCentralGoogle Scholar
  4. Townsend DM, Tew KD (2003) The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22:7369–7375CrossRefPubMedGoogle Scholar
  5. Wu Y, Fan Y, Xue B et al (2006) Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene 25:5787–5800CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.College of Life ScienceNanjing Normal UniversityNanjingPeople’s Republic of China