Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Gankyrin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2323-2

Synonyms

Definition

Gankyrin (Gann ankyrin-repeat protein; “Gann” in Japanese means cancer) is a small 25kD 226-amino acid protein originally identified as the product of an oncogene commonly overexpressed in human hepatocellular carcinoma (HCC). Independently, it was purified as the p28 component of the 19S regulator (PA700 complex) of the 26S proteasome. The gene is localized on human chromosome Xq22.3 and produces at least nine transcript variants encoding nine distinct proteins. Gankyrin associates with cyclin-dependent kinase 4 (CDK4) to control the phosphorylation of the retinoblastoma protein pRB and with the E3 ubiquitin ligase MDM2 to control the ubiquitylation and degradation of p53 (and possibly pRB).

Characteristics

Gankyrin is a small cytoplasm–nucleus shuttling protein highly conserved throughout evolution (∼40 % identity to yeast Nas6p). Structurally, gankyrin consists of seven, not five or six as originally suggested by its amino acid sequence, ankyrin repeats...

Keywords

Acute Lymphoblastic Leukemia Ankyrin Repeat Early HCCs Motif LxCxE PA700 Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Higashitsuji H, Itoh K, Fujita J et al (2000) Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin repeat protein overexpressed in hepatomas. Nat Med 6:96–99CrossRefPubMedGoogle Scholar
  2. Iakova P, Timchenko L, Timchenko NA (2011) Intracellllular signaling and hepatocellular carcinoma. Semin Cancer Biol 21:28–34CrossRefPubMedGoogle Scholar
  3. Su B, Luo T, Wang H et al (2015) Interleukin 1beta/linterleukin 1 receptor associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology 61:585–597CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Molecular Biology, Graduate School of MedicineKyoto UniversityKyotoJapan