Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Fucosylation

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2272-2

Definition

Fucosylation is defined as an attachment of fucose residue to N- or O-glycans on glycoproteins as well as glycolipids. In many types of glycosylation, fucosylation is one of the most important glycosylation involved in cancer and inflammation. Fucosylation is regulated by a set of fucosyltransferases, their donor substrate GDP-fucose, and GDP-fucose transporter, which transfer GDP-fucose from cytosol to Golgi apparatus. While fucosylation levels are increased in most cancers, complete loss of fucosylation is observed in specific cases of cancer cell lines as well as cancer tissue. Cancer cells with loss of fucosylation showed more aggressive phenotypes in terms of an escape from tumor immune surveillance and tumor metastasis.

Characteristics

Finding of Fucosylation-Deficient Cancer Cell Lines

GDP-fucose is synthesized in cytosol via de novo and salvage pathways. In the de novo pathway, which plays a major role in the GDP-fucose synthesis of many cells,...

Keywords

Natural Killer Cell Colon Cancer Cell Line Ovarian Cancer Tissue Growth Factor Receptor Signaling Lectin Blot 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Core fucose. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 979. doi:10.1007/978-3-642-16483-5_1334Google Scholar
  2. (2012) FX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1479. doi:10.1007/978-3-642-16483-5_2289Google Scholar
  3. (2012) GDP-fucose. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1516. doi:10.1007/978-3-642-16483-5_2352Google Scholar
  4. (2012) Lectin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1999. doi:10.1007/978-3-642-16483-5_3303Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Molecular Biochemistry & Clinical InvestigationOsaka University Graduate School of MedicineSuitaJapan